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生科院潘飞燕-郭志刚课题组揭示“组蛋白密码”在DNA氧化损伤修复中的新机制

极速飞艇2020NIAN7YUE29RI,SHENGKEYUANPANFEIYAN-GUOZHIGANGJIAOSHOUKETIZUZAIDNASUNSHANGXIUFUFANGMIANDEYANJIUCHENGGUOYI“Symmetrical dimethylation of H4R3: A bridge linking DNA damage and repair upon oxidative stress "WEITIZAIXIANFABIAOZAIRedox BiologyZAZHISHANG,GAIZAZHISHIYANGHUAHAIYUANLINGYUDEZUIQUANWEIQIKAN,YINGXIANGYINZI9.986。SHUOSHISHENGMAZHUANG、WANGWENTAOWEILUNWENDEGONGTONGDIYIZUOZHE,PANFEIYANFUJIAOSHOUHEGUOZHIGANGJIAOSHOUWEIBINGLIETONGXUNZUOZHE。LUNWENLIANJIE:。

ZAISHENGMINGHUODONGGUOCHENGZHONG,XIBAOHUIBUDUANZAOSHOUNEIYUANHEWAIYUANYINSUYINQIDEYANGHUAYALI,CONGERCHANSHENGGUODUODEHUOXINGYANGFENZI(reactive oxygen species,ROS),ROSFEITEYIXINGDIGONGJIBAOKUODNAHEDANBAIZHIZAINEIDESHENGWUDAFENZI。QIZHONG,DNASHIZUIZHUYAODEBABIAO,YANGHUADEDNARUGUOBUBEIJISHIXIUFU,HUIZAIDNAFUZHIGUOCHENGZHONGXINGCHENGCUOPEI,YINQIJIYINZUDEBUWENDING,ZUIZHONGDAOZHIZHONGLIUJIMOUXIETUIXINGXINGJIBINGDEFASHENG。JITIFAZHANCHUDUOTIAOTUJINGDUIYANGHUASUNSHANGDEDNAJINXINGXIUFU,QIZHONGJIANJIQIECHUXIUFU(BER)SHIXIBAONEIDNAYANGHUASUNSHANGDEZHUYAOXIUFUTUJING。YANJIUBERDANBAIRUHEXIANGYINGYANGHUAYINGJIXINHAOBINGJINXINGYOUXUGAOXIAODEXIUFUDUIYULINCHUANGJIBINGFASHENGDEJILIJUYOUZHONGYAODELILUNYIYIHELINCHUANGJIAZHI。

ZUDANBAIZAITEDINGDESHENGLIQINGKUANGXIAHUIFASHENGFANYIHOUXIUSHI,CONGERTIGONGYIZHONGSHIBIEBIAOZHI,WEIQITADANBAIYUDNADEJIEHECHANSHENGXIETONGHUOZHEJIEKANGXIAOYING,TONGCHANGBEIRENWEIYUZHUANLUDIAOKONGMIQIEXIANGGUAN。SHENGKEYUANGUOZHIGANGJIAOSHOUKETIZUYANJIUFAXIAN,ZUDANBAIDEFANYIHOUXIUSHIBUJINCANYUZHUANLUDIAOKONG,ZAIDNASUNSHANGXIUFUZHONGYEJUYOUJIWEIZHONGYAODEZUOYONG。ZAIYANGHUAYINGJIXIA,ZUDANBAIH4WEIBUDISANWEIJINGANSUANDUICHENGXINGDEJIAJIHUAXIUSHI(H4R3me2s)HUIXIANZHUSHANGSHENG,QIZAIDNAYANGHUASUNSHANGXIUFUZHONGCHONGDANGZHEQIAOLIANGJIAOSE:DNAYANGHUASUNSHANGXINHAOTONGGUO8-oxoG/OGG1/PRMT5CHUANDIDAOH4R3me2s,H4R3me2sDECHANSHENGYOULIYURANSEZHIJIEGOUDEDAKAI,QIJINYIBUZHAOMUXIUFUGUANJIANDANBAIFEN1LAIZHIXINGDNAXIUFUGONGNENG,CONGERWEICHIJIYINZUDEWENDING。GAIYANJIUSHENRUCHANMINGLE“ZUDANBAIMIMA“JIESHOUSUNSHANGXINHAOBINGSHUCHUXINHAODEGUOCHENG,DUIJITIRUHEZAIYANGHUAYINGJIXIAWEICHIJIYINZUWENDINGXINGTIGONGLEGENGWEIXIZHIDEJIESHI。


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    2020NIAN07YUE31RI 11:24

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